Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary Targetcysteine proteases

General description

Irreversible inhibitor of cysteine proteases. Has no action on cysteine residues in other proteins. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV⁺ donors. Specific active site titrant.

Irreversible inhibitor of cysteine proteases. Interacts with the S_n subsites of proteases. Has no action on cysteine residues in other proteins. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV⁺ donors. Specific active site titrant.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Matsumoto, K., et al. 1999. Biopolymers51, 99.Sarin, A., et al. 1994. J. Immunol.153, 862.Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.Barrett, A.J. 1982. Biochem. J.201, 189.

Packaging

25 mg in Glass bottle

1, 5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Warning

Toxicity: Standard Handling (A)